Stromal Protein-Mediated Immune Regulation in Digestive Cancers

Cathepsins in digestive cancers

Cathepsins are lysosomal peptidases belonging to the papain family, and based on their catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases. The studies conducted to date have identified, 15 types of cathepsins that are widely distributed in intracellular and extracellular spaces. These proteases participate in various pathological activities, including the...

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers.

The stromal compartment is increasingly recognized to play a role in cancer. However, its role in the transition from preinvasive to invasive disease is unknown. Most gastrointestinal tumors have clearly defined premalignant stages, and Barrett's esophagus (BE) is an ideal research model. Supervised clustering of gene expression profiles from microdissected stroma identified a gene signature th...

Regulation in Sepsis Apolipoprotein E-Mediated Immune

Digestive cancers in Morocco: Fez-Boulemane region

INTRODUCTION To describe the epidemiological and pathological aspects of gastrointestinal cancers in Fez-Boulemane. METHODS This was a retrospective descriptive study of 1120 gastrointestinal cancers diagnosed between 2004 and 2010 in the department of Pathology of Hassan II University Hospital in Fez Morocco. RESULTS The average age of our patients was 53 years with a male predominance in ...

Role of protein glycosylation in immune regulation.

Most cell surface and secreted proteins are glycosylated that is, they have one or more oligosaccharide chains covalently attached to specific amino acids. These oligosaccharides usually make up a significant amount of the hydrodynamic mass of the molecules and also have effects on protein conformation, surface expression, stability, circulating half life, activity, and antigenicity. In additio...